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Conclusion

Diabetes mellitus is the most common endocrine/metabolic disorder affecting approximately
10% of the population with a tendency for further growth. Such a high prevalence implies that
dentists frequently encounter individuals with diabetes in their practice. Diabetes has various oral
manifestations that may be the reason for a visit to the dental office. Every dentist needs to be
familiar with the basic characteristics of diabetes, especially its acute complications, to recognize

them promptly and apply appropriate therapeutic measures. Before any dental procedure or
intervention, an evaluation of patients with diabetes of varying extent is necessary, depending on
the type, urgency, and planned duration of the dental intervention. The most important aspect is
that diabetes is well-controlled, best confirmed by normal (or acceptable) levels of glycosylated
hemoglobin. All diagnostic and therapeutic measures aimed at preventing and treating acute
complications of diabetes must be in line with the recommendations of the National Guidelines for
the Diagnosis and Treatment of Diabetes. Every dental office must-have equipment for measuring
blood glucose from capillary blood, as well as the recommended means for treating hypoglycemia,
while patients with diabetic ketoacidosis or other hyperglycemic complications must be hospitalized.

Literature 15. Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, et
al. Periodontal manifestations of systemic diseases and developmental
and acquired conditions: Consensus report of workgroup 3 of the 2017
1. ADA. Dijabetes—2023. Classification and Diagnosis of Diabetes: World Workshop on the Classification of Periodontal and Peri-Implant
Standards of Care in Diabetes Care 2023;46(Suppl. 1):S19–S40 Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S237-S248.
2. Kalezić N, Stevanović V, Jovanović K, Karadžić-Kočica M, Lalić K. 16. Karmakar S, Kar A, Thakur S, Rao VUS. Periodontitis and oral Cancer-A
Perioepartivno lečenje bolesnika sa dijabetesom melitusom, u: Kalezić striking link. Oral Oncol. 2020 Jul;106:104630.
N. Perioperativna medicina 2, 2021; 21:493-526. 17. Casillas Santana MA, Arreguín Cano JA, Dib Kanán A, Dipp Velázquez FA,
3. ADA. Diabetes Care 2023;46(Suppl. 1):S5–S9 | Munguía PDCS, Martínez Castañón GA, et al. Should We Be Concerned
about the Association of Diabetes Mellitus and Periodontal Disease
4. Centers for Disease Control and Prevention. National Diabetes Statistics in the Risk of Infection by SARS-CoV-2? A Systematic Review and
Report, 2020. Atlanta, GA: U.S. Department of Health and Human Hypothesis. Medicina (Kaunas). 2021 May 13;57(5):493.
Services, 2020. Avilable on: https://www.cdc.gov/diabetes/pdfs/data/
statistics/national-diabetes-statistics-report.pdf 18. Bloomgarden ZT. Diabetes and COVID-19. J Diabetes. 2020
Apr;12(4):347-8.
5. ADA. Diabetes Care 2023; Summary of Revisions: Standards of Care in
Diabetes-2023 19. Sampson V, Kamona N, Sampson A. Could there be a link between
oral hygiene and the severity of SARS-CoV-2 infections? Br Dent J. 2020
6. Verhulst MJL, Loos BG, Gerdes VEA, Teeuw WJ. Evaluating All Potential Jun;228(12):971-5.
Oral Complications of Diabetes Mellitus. Front Endocrinol (Lausanne).
2019 Feb 18;10:56. 20. Pitones-Rubio V, Chávez-Cortez EG, Hurtado-Camarena A, González-
Rascón A, Serafín-Higuera N. Is periodontal disease a risk factor for
7. Kocić R. Endokrine bolesti od značaja za stomatološku praksu. U: severe COVID-19 illness? Med Hypotheses. 2020 Nov;144:109969.
Stanković D, Jovanović G. Problematika bolesti rizika u stomatološkoj
praksi.Medicinski fakultet Univerziteta u Nišu, Niš; 2011; p-105-39. 21. Chen L, Zhao J, Peng J, Li X, Deng X, Geng Z, et al. Detection of SARS-
CoV-2 in saliva and characterization of oral symptoms in COVID-19
8. Republička stručna komisija za izradu i implementaciju vodiča dobre patients. Cell Prolif. 2020 Dec;53(12):e12923.
kliničke prakse. Nacionalni vodič dobre kliničke prakse za dijagnozu
i lečenje diabetes mellitus-a, Ministarstvo zdravlja Republike Srbije. 22. Tan SJ, Baharin B, Nabil S, Mohd N, Zhu Y. Does glycemic control have a
Drugo izmenjeno i dopunjeno izdanje, 2012. dose-response relationship with implant outcomes? A comprehensive
systematic review and meta-analysis. J Evid Based Dent Pract. 2021
9. Walker RJ, Garacci E, Campbell JA, Egede LE. The influence of daily stress Jun;21(2):101543.
on glycemic control and mortality in adults with diabetes. J Behav Med.
2020 Oct;43(5):723-31. 23. Shang R, Gao L. Impact of hyperglycemia on the rate of implant
failure and peri-implant parameters in patients with type 2 diabetes
10. Stöhr J, Barbaresko J, Neuenschwander M, Schlesinger S. Bidirectional mellitus: Systematic review and meta-analysis. J Am Dent Assoc. 2021
association between periodontal disease and diabetes mellitus: a Mar;152(3):189-201.e1.
systematic review and meta-analysis of cohort studies. Sci Rep. 2021 Jul
1;11(1):13686. 24. Khawaja NA, Khalil H, Parveen K, Alghamdi AM, Alzahrani RA, Alherbi
SM. An influence of adrenaline (1:80,000) containing local anesthesia
11. Preshaw PM, Bissett SM. Periodontitis and diabetes. Br Dent J. 2019 (2% Xylocaine) on glycemic level of patients undergoing tooth
Oct;227(7):577-84. extraction in Riyadh. Saudi Pharm J. 2014 Dec;22(6):545-9.
12. Stanković D, Janković G. Stomatološki aspekti pacijenata sa šećernom 25. Santos-Paul MA, Neves IL, Neves RS, Ramires JA. Local anesthesia with
bolešću. U „Problematika bolesti rizika u stomatološkoj praksi“, 2011; epinephrine is safe and effective for oral surgery in patients with type
p:114-20. 2 diabetes mellitus and coronary disease: a prospective randomized
study. Clinics (Sao Paulo). 2015 Mar;70(3):185-9.
13. Leblhuber F, Huemer J, Steiner K, Gostner JM, Fuchs D. Knock-on effect
of periodontitis to the pathogenesis of Alzheimer's disease? Wien Klin 26. Nassif N, Noueiri B. Dental Treatment Effect on Blood Glucose Level
Wochenschr. 2020 Sep;132(17-18):493-8. Fluctuation in Type 1 Balanced Diabetic Children. Int J Clin Pediatr Dent.
2021 Mar-Apr;14(2):212-6.
14. Chen ZY, Ye LW, Zhao L, Liang ZJ, Yu T, Gao J. Hyperuricemia as a
potential plausible risk factor for periodontitis. Med Hypotheses. 2020
Apr;137:109591.
74 DOI: 10.5937/Galmed2409080D